DEPARTMENT OF CRYOPATHOPHYSIOLOGY AND IMMUNOLOGY

Headed by:
Academician of the National Academy of Sciences of Ukraine, Prof., MD,
Honored Worker in Science and Technology of Ukraine
Anatoliy M. GOLTSEV
HISTORY OF THE DEPARTMENT

In 1993, the Department of Cryopathophysiology was organized on the basis of the Laboratory of Cryobiology of Hematopoietic and Monocyte-Macrophage Systems of Cryoimmunology Department of the IPCC. The Department was created with the aim of developing at the IPCC the direction of research related to the study of the mechanisms of development of autoimmune and oncology diseases, as well as the pathophysiological grounds of the interaction of cryopreserved cells of bone marrow, fetal liver, neuronal cells, placenta, cord blood and others with the recipient’s organism with the above pathologies. In 2008 The Department of Cryopathophysiology was reorganized into the Department of Cryopathophysiology and Immunology. In 2016, the Department of Cryopathophysiology and Immunology embraced the Biotechnology and Applied Nanotechnology Group.
Since the establishment of the Department it has been headed by Anatoliy M. GOLTSEV – an outstanding scientist-cryobiologist, MD, Prof., Academician of the National Academy of Sciences of Ukraine. He has authored 1,137 scientific papers, including 13 monographs, 54 patents. Under his leadership, 4 doctoral and 22 candidate theses were defended.

RESEARCH DIRECTIONS

  • Study of the pathophysiological grounds  and mechanisms of development of autoimmune and oncology diseases, features of interaction of cryopreserved cells and tissues (including fetal) with the organism of recipients with the above pathologies.
  • Improvement of cryopreservation methods for stem cells of different potency levels in order to level non-lethal cryodamages and increase the efficiency of clinical use.
  • Fundamental research of cryosensitivity of stem cancer cells and use of various forms of nanocomposites in order to increase the efficiency of treatment of oncopathology.
  • Development of protocols for effective cryopreservation of spermatogonial stem and accessory regulatory cells of the testicles and convoluted tubule tissues using biopolymer gels to restore male fertility
  • Study of the features of the influence of cryopreservation on the state of genomic-postgenomic cascades of stem and accessory regulatory cells of various origins.
  • Use of various forms of nanocoatings as a culture substrate for the purpose of directed change of structural and functional properties of mesenchymal stem cells during in vitro cultivation.
  • Creation of biotechnologies for ex vivo cultivation of dendritic cells from cryopreserved precursor cells and study of molecular mechanisms of tolerogenic activity in order to enhance the effectiveness of their clinical application.
  • Modernization of cryopreservation and lyophilization techniques of cord blood components to obtain antiviral drugs – immunocorrectors that are effective in clinical practice.
  • Cooperative interactions with certain departments of the institute in order to improve technologies for low-temperature storage of strategic blood  stocks.
CURRENT STUDIES
  • Study of the mechanisms of activation of tolerogenic activity of dendritic cells under the influence of cryopreservation and cord blood components
  • Study of the rehabilitation mechanisms of immune system of tumor-bearing animals by cryopreserved dendritic cells”
  • Cryopreservation of spermatogonial stem and accessory regulatory cells of the testes using biopolymer gels
  • Combined use of nanocomposites and ultra-low temperatures for inactivation of tumorigenic cells and inhibition of tumor growth within the frames of Target program of fundamental research of the NAS of Ukraine “Promising fundamental research and innovative developments of nanomaterials and nanotechnologies for the needs of industry, healthcare and agriculture”.
  • Use of modern cell nanobiotechnologies in therapy of rheumatoid arthritis within the frames of  Target program of scientific research of the NAS of Ukraine “Genomic, molecular and cellular foundations of the development of innovative biotechnologies”

 DEPARTMENT STAFF

The department employs 1 Doctor of Sciences and 9 Candidates of Sciences.

GROUP OF BIOTECHNOLOGY AND APPLIED NANOTECHNOLOGIES

CONTACT INFORMATION

Tetiana DUBRAVA
e-mail: cryopato@gmail.com
+38 (050) 593-49-31

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