Main areas of the Department activity
1) Isolation, cultivation and studying of the stem cell properties
- Multipotent mesenchymal stromal cells (MSCs) from various sources (bone marrow, adipose tissue, adult dermis, tooth germ pulp, placenta, fetal tissues)
- Neural stem cells
- In vitro and in vivo study of biological properties and therapeutic potential of stem and progenitor cell bioregulators obtained by cultivating MSCs from various sources
2) Three-dimensional (3D) cultivation of MSCs in alginate microspheres and macroporous matrices, creation of bioengineered constructs
- Cultivation of MSCs in spheroids
- Cultivation of MSCs in alginate microspheres
- Cultivation of MSCs in macroporous matrices of natural origin and artificially created from various materials (alginate, collagen, gelatin, chitin, chitosan, etc.).
3) Development of technologies for storing stem cells as the suspensions and as part of three-dimensional structures, placenta derivatives
- Cryopreservation by slow freezing (in the absence or reduction of the concentration of xenogeneic components)
- Cryopreservation of MSCs by vitrification as part of suspension and three-dimensional structures
- Hypothermal storage of cells and tissue engineering constructs
4) Experimental transplantation of stem cells
- In rats’ models of liver failure
- In murine model of skin excision wound
- In rat’s model of burns
- In rat’s model of spinal and brain injuries
- In rat’s model of gynecology pathology
5) Hypothermal storage of isolated liver
- There has been developed and patented a medium for storing isolated liver
- Optimization of the organ preservation medium using components that affect mitochondrial function and stem cell bioregulators
International cooperation
- Institute for Multiphase Processes, Germany (10 joint publications)
- Institute of Experimental Physics, Freiberg, German (8 joint publications)
- UCL Medical School, London, UK (35 joint publications)
- Institute of Experimental Medicine, Czech Republic; (9 joint publications)
- Tel-Aviv University, Israel (4 joint publications)
- Nottingham University, UK (6 joint publications)
- MRC Clinical Research Center (CRC) at Northwick Park (4 joint publications)
Cooperation with Ukrainian institutions
- National Scientific Center “Kharkiv Institute of Physics and Technology” (3 publications)
- SSI “Institute for Single Crystals ( investigation of the properties of dyes, nanoparticles, J-aggregates – 3 publications
- Sytenko Institute of Spine and Joint Pathology of the NAMS of Ukraine” (2 publications).
- Kharkiv National Medical University (conducting a Damage Control course, 3 publications)
- NGO “MEKHAD” (conducting a Damage Control course)
- SumSU studies of neuroconduit and osteoimplants – 2 publications)
- National University of Pharmacy (conducting training for masters and teachers, investigations of the properties of nitrosamines, plant extracts, joint publication)
- Danylevsky Institute for Endocrine Pathology Problems of the National Academy of Medical Sciences of Ukraine” (2 publications)
- Karazin’s Kharkiv National University ( 4 publications)
The Department staff is tightly involved into the education activities via lecturing in many institutions in the city of Kharkiv, as well as they are performing expertise in National scientific councils and societies there.
